Expand Cut Tags

No cut tags

The Friday Five for 14 November 2025

Nov. 13th, 2025 06:14 pm
anais_pf: (Default)
[personal profile] anais_pf posting in [community profile] thefridayfive
These questions were originally suggested by [livejournal.com profile] alysonl.

1. What's one of the nicest things a friend has ever done for you?

2. What's one of the nicest things a stranger has ever done for you?

3. What is a trait in another person that you instantly admire, and that draws you to them?

4. What is a trait in another person that instantly repels you, and prevents you from forming a close relationship with them?

5. Time to vent: tell us about something rotten someone has done to you.

Copy and paste to your own journal, then reply to this post with a link to your answers. If your journal is private or friends-only, you can post your full answers in the comments below.
[syndicated profile] lois_mcmaster_bujold_feed
I'm very pleased to report that the most recent Penric & Desdemona novella, "Testimony of Mute Things", has just been licensed to Blackstone Audiobooks for its usual production. Narrator is again expected to be Grover Gardner.

No, I don't know when it will emerge from the other end of the production pipeline; prior experience suggests 2 to 6 months, probabilities leaning to the shorter end.

Re-using Ron Miller's art, which they've been doing for a while, should help speed things up on their vendor-page assembly. I've no idea what arcana is involved in recording, except I'm glad it's them and not me.

Subterranean Press has also offered for the novella. They'll have a much longer lead-time, probably into 2027, so breath-holding is contraindicated. I did get a look at Lauren Saint-Onge's final art for their upcoming "The Adventure of the Demonic Ox", which is particularly lovely this round. Publication sometime in the first half of 2026, I don't have a date yet. (Or the 1300 tip sheets to be signed, another necessary precursor. That will be a nice brainless task for this winter.)

Ta, L.

posted by Lois McMaster Bujold on November, 13

bad/good

Nov. 13th, 2025 10:03 pm
trobadora: (Sheppard \o/)
[personal profile] trobadora
Bad things:
  • Ten-hour days at work.

  • Brains that are mush and will not word.

  • Too many appointments next week, on top of work.

Good things:
  • Super mild November weather that let me ride a bike today (during my lunch break) without getting chilled. And tomorrow again, it looks like!

  • Delicious home-cooked food from the freezer that only needs heating up with zero effort on my part. (Thanks, past me!)

  • [community profile] ficinabox has a two-week extension! Now I can expand that thing I wanted to expand. :D

  • [community profile] fandomtrees is open for sign-ups!

In conclusion, the good things are better than the bad things are bad. Yay? *g*

Biochemical Tungsten - Really

Nov. 13th, 2025 02:23 pm
[syndicated profile] in_the_pipeline_feed

Here’s another example of biochemistry being weird, one that I had never come across until recently. Did you know that there are enzymes that are dependent on tungsten (of all things?) As far as we know, they aren’t found in higher organisms, but they are scattered across a number of bacteria and archaea. There’s a whole related family of molybdenum-dependent enzymes that I had heard about, but there is indeed a group that can only use tungsten.

Both of these types tend to have similar environments immediately around the metal, with a heterocycle called “molybdopterin” involved in complexing the metal ions themselves (though the two thiols in the structure). Several magnesium ions help to hold things in place. There is even a rare human genetic disorder that traces back to an inability to produce this cofactor, a deficiency with very severe results.

The enzymes that use these metallo-centers are largely oxidoreductases, but the obligate tungsten forms in the bacteria and archaea also include such exotica as acetylene hydratase. These tend to be found in anaerobic organisms, and these reactions are unusual enough to be of potential industrial importance. For example, Clostridium autoethanogenum (as its name implies!) is able to produce ethanol from the unlikely starting material of syngas (a mixture of hydrogen, carbon monoxide, and carbon dioxide), and this is actually being scaled up for large-scale use. And it now turns out that a key enzyme in this pathway is one of the tungsten-dependent variety, reducing acetate to acetaldehyde in a step that you probably would have modeled as thermodynamically unfeasible if you didn’t know the whole system it’s imbedded in (which features a key electron-transport step involving very low-potential electrons of the sort that you don’t usually see in biochemical systems). The immediate reduction to ethanol of the acetaldehyde thus produced (via a nearby alcohol dehydrogenase enzyme) helps keep things moving as well, while other factors are an intracellular pH that’s notably less acidic than the outside medium and a high tolerance for acetate buildup.

Knowing these details is of course important if you’re trying to optimize the bacteria to do your syngas valorization for you, and it’s also something you have to understand if you want to shoot for a cell-free process using only the enzymes. As the paper explains, though, there are still a number of mysteries, especially around the details of the tungsten center’s changing oxidation state and coordination chemistry as the reaction cycle goes along. 

Personally, I’m very happy to find that there might be another biotechnology route to remediating industrial gas emissions, and I’m also pleasantly surprised that tungsten, of all things, is a necessary metal for life in some species. The way that these two subjects intersect is what science is all about - you never could have predicted it!

 

A certain concurrence here....

Nov. 13th, 2025 07:32 pm
oursin: Photograph of James Miranda Barry, c. 1850 (James Miranda Barry)
[personal profile] oursin

Noted as of interest a day or so ago, ‘I don’t want anyone to suffer like I did’: the intersex campaigners fighting to limit surgery on children - am a bit gloomed to think that this is Still An Issue because I look back and surely this was brought to wider attention, oh, at least twenty or years ago?

Ah. A little delving shows me that the person I remember as doing pioneering research on the subject, published around the late 90s, and also involved in intersex activism, has become A Figure of Controversy and I think we probably do not mention them.

But quite coincidentally this emerged today: who, according to work done by A Very Reputable Scientist sequencing DNA which does appear to be his, had a Disorder of Sexual Development (as intersex conditions are sometimes termed)? Did Hitler really have a ‘micropenis’? The dubious documentary analysing the dictator’s DNA.

Here is a thoughtful and nuanced piece by an actual scientist taking issue with some of the more tabloidy accounts A slightly different take on the news that Hitler’s DNA reveals some genetic anomalies. The most interesting thing to me is that history has a profound capability for irony.

That Hitler himself had a condition that was discovered and named by a Jewish man who also held some responsibility for the scientifically misguided murderous policies of the Nazis is at least a reflection that history is often imbued with a sense of complex and confusing irony.

elisem: (Default)
[personal profile] elisem
 The status around here is STILL RESTING LIKE A POTATO, though yesterday I did give in to "this needs to be done, it is a safety issue, and I'm the only one who's likely to do it." Thus the two small stumps at the edge of the yard are now decorated with strips of rag tied around them in a way that, one hopes, will convey the notion that there is something here which should neither be mowed over nor tripped over. Also I stuck a few sunflower stalks in a brush bag. And then I came in to potato some more.

thursday

Nov. 13th, 2025 01:40 pm
summersgate: (Default)
[personal profile] summersgate
1000004121.jpg
The view this afternoon from my window. It's been lovely lying on my bed with intermittent clouds and then the sun flooding in and warming me. Watching the clouds float over is relaxing. I'm glad I got the window bed. I'm done with my tests (echocardiogram and stress test) and am just waiting to hear the results of the stress test so I can go home this afternoon. I doubt there will be a problem. Thank you everyone for your good wishes! It'll be good to get home to Dave, Little Rainy, Andy, Skye and the chickens. I am feeling a greater appreciation for them at the moment.

365 Questions 2025

Nov. 13th, 2025 01:21 pm
maju: Clean my kitchen (Default)
[personal profile] maju
8. Who was the last person you said “I love you” to? One of my granddaughters. I forget which one; I tell each of them regularly that I love them.

9. What is your biggest phobia? I had a few mild phobias when I was living alone in Maryland (e.g. a tree falling on the house during a storm, something catastrophic happening to me and not being able to get help) but I feel much safer here at my daughter's so now I wouldn't say I have any phobias. (And I'm not sure the examples I gave would be considered actual phobias.) One thing I've discovered since arriving here that I didn't know before is that Aria has a phobia of bugs, even ladybugs.

10. What are some recent compliments you’ve received? I can't think of any.

11. How many friends do you have in real life that you talk to regularly? A couple.

12. How much money per month is enough for you to live comfortably? This very much depends on where I'm living. It was much cheaper for me to live in Australia than it is here, even allowing for inflation over the last 15 years or so.

13. When was your first impression of someone totally wrong? I can't remember that happening.

(no subject)

Nov. 13th, 2025 01:11 pm
maju: Clean my kitchen (Default)
[personal profile] maju
I keep getting emails from Medicare reminding me that I should have a "Welcome to Medicare" appointment before 1st February (the date I got Medicare Part B coverage this year), so yesterday I spent quite a while on the phone trying to organise this. I checked the Medicare website for doctors and NPs in this area who take Medicare, then called the number for an NP who sounded promising. It took ages to get through to an actual person, but when I did, she seemed a bit vague about this "Welcome to Medicare" thing, plus she said my chosen person doesn't have any appointments available until the first week of February. When I said I needed the appointment before then, she found someone else (at a different practice) who can see me next week. However, when she asked about my insurance, she seemed to ignore the fact that I have Medicare, and because I'm still waiting for S's work to sign me up for a new policy with a company that operates in this area, she said she would put me down as "self pay", and didn't take any details of my Medicare policies even though when I asked if this person takes Medicare, she said yes, she does. Therefore I have an invoice for $131 for this upcoming appointment.

I haven't paid this invoice yet, and this morning I was able to enter the details of my Medicare policies (A/B and Medigap) into my new MyChart account, and I'm hoping that this will cover the $131. Actually, $131 is only about 25% of the cost of the appointment, so maybe Medicare is covering the rest? American health insurance is still an almost total mystery to me.

Better

Nov. 13th, 2025 09:32 am
susandennis: (Default)
[personal profile] susandennis
Tuesday's volleyball left me not interested in ever playing again. Today's volleyball saved the day. It was fun and invigorating.

Major cult news in today's Timber Ridge Times... Julie is retiring at the end of the year. Julie is the hair dresser. She knows EVERYTHING about EVERYBODY. She's also delightful. And come January she'll be gone. This is big. Really big. She does the hair of everyone - men and women - except me. And, on Mondays, she spends the day in Briarwood - which houses assisted living, the nursing rooms and the memory care unit.

Having someone else do their hair is huge for some of these old people. It will give them something to bitch about for months on end. I can hear Joan now.

And, also, they have finally found a nail person who will be starting soon. Everyone will be all atwitter about this one. I can't wait until elbow coffee on Saturday!

This morning, I am going to pop over to QFC to buy wine. I never drink wine but a couple of weeks ago, at dinner, Bonny pulled out a bottle of Cabernet and offered it up. It was delicious. It turns out to be pretty cheap wine that also keeps well (with a vacuum sealer) so I decided to get some. The internets say it's at QFC and Fred Meyers. Neither place has it on the shelf that I can see nor did they have anyone to ask when I was there. Now I am on a fucking quest. QFC said the wine guy was there in the mornings. So I'm going back this morning to see if I can find him or the friggin wine.

And, really, that's the extent of my to-do list. As it stands now.

Oh wait, no. I do need to cut my hair. Maybe I'll go do that now.

20251112_193747-COLLAGE

Saori WX60

Nov. 13th, 2025 10:20 am
yhlee: Alto clef and whole note (middle C). (Default)
[personal profile] yhlee
They're not kidding when they say this loom folds up easily (a few seconds) and can be wheeled WITH A PARTIALLY WOVEN WIP STILL ON THE LOOM, ditto unfolding and your project's ready again. (The wheels are extra, but worth it to me.)

Note that this loom is lightweight, my preference (~30 lbs) but that means it will "travel" if you treadle hard. Likewise, by default it's only two harnesses. I unironically love plainweave so this is fine for my use case but if you have more complex weaving in mind, maybe not so much. (You can buy a spendy attachment to convert it to four harnesses, but...)

folded loom Read more... )

I haven't yet tested it, but the design of the "ready-made warp" tabletop system is fiendishly clever. Frankly, warping is potentially so annoying that it was worth the cost. I am considering a Frankenstein's monster modification that MIGHT make warping easier as well but I haven't yet tested it.

tabletop warping system
[syndicated profile] lilisonna_tumblr_feed

mossdftba:

gaybichon:

gaybichon:

gaybichon:

this is the full video of patti lupone breaking the sound barrier at the 1988 tony awards btw

it’s patti lupone’s birthday have you listened to her breaking the sound barrier at the 1988 tony awards?

@bloodanna i’m stealing your tags bc it’s a good explanation of what’s going on!!!

Image transcript: I feel like this is such a good example of how a well-trained performer can allow the performance space to shape them. Like Patti Lupone can belt! Her projection as she sings can be incredible especially when she was young. But the acoustics of a space have a limit and if you hit that limit then the sound echoes back and throws the harmonies out of wack. You can hear that in the beginning. The echo of her voice is almost like feedback and it makes a really strong pure note sound kind of jarring. And so she adjusts until she is hitting the notes and belting within the limits of the space. Producing a sound that fills the theatre but doesn’t echo back over itself. Except in places where that would enhance the song. where the echo almost becomes another harmony. Top Tier performance and display of mastery over her craft. End transcript.

emotional support spinning

Nov. 13th, 2025 07:15 am
yhlee: Alto clef and whole note (middle C). (Default)
[personal profile] yhlee
Possum blend from Ixchel, two-ply!

I still love the wallaby blend best, but this is great too.

handspun yarn

Book Review: The Business of Secrets

Nov. 13th, 2025 12:09 pm
[syndicated profile] bruce_schneier_feed

Posted by Bruce Schneier

The Business of Secrets: Adventures in Selling Encryption Around the World by Fred Kinch (May 24, 2004)

From the vantage point of today, it’s surreal reading about the commercial cryptography business in the 1970s. Nobody knew anything. The manufacturers didn’t know whether the cryptography they sold was any good. The customers didn’t know whether the crypto they bought was any good. Everyone pretended to know, thought they knew, or knew better than to even try to know.

The Business of Secrets is the self-published memoirs of Fred Kinch. He was founder and vice president of—mostly sales—at a US cryptographic hardware company called Datotek, from company’s founding in 1969 until 1982. It’s mostly a disjointed collection of stories about the difficulties of selling to governments worldwide, along with descriptions of the highs and (mostly) lows of foreign airlines, foreign hotels, and foreign travel in general. But it’s also about encryption.

Datotek sold cryptographic equipment in the era after rotor machines and before modern academic cryptography. The company initially marketed computer-file encryption, but pivoted o link encryption – low-speed data, voice, fax – because that’s what the market wanted.

These were the years where the NSA hired anyone promising in the field, and routinely classified – and thereby blocked – publication of academic mathematics papers of those they didn’t hire. They controlled the fielding of strong cryptography by aggressively using the International Traffic in Arms regulation. Kinch talks about the difficulties in getting an expert license for Datotek’s products; he didn’t know that the only reason he ever got that license was because the NSA was able to break his company’s stuff. He had no idea that his largest competitor, the Swiss company Crypto AG, was owned and controlled by the CIA and its West German equivalent. “Wouldn’t that have made our life easier if we had known that back in the 1970s?” Yes, it would. But no one knew.

Glimmers of the clandestine world peek out of the book. Countries like France ask detailed tech questions, borrow or buy a couple of units for “evaluation,” and then disappear again. Did they break the encryption? Did they just want to see what their adversaries were using? No one at Datotek knew.

Kinch “carried the key generator logic diagrams and schematics” with him – even today it’s good practice not to rely on their secrecy for security—but the details seem laughably insecure: four linear shift registers of 29, 23, 13, and 7 bits, variable stepping, and a small nonlinear final transformation. The NSA probably used this as a challenge to its new hires. But Datotek didn’t know that, at the time.

Kinch writes: “The strength of the cryptography had to be accepted on trust and only on trust.” Yes, but it’s so, so weird to read about it in practice. Kinch demonstrated the security of his telephone encryptors by hooking a pair of them up and having people listen to the encrypted voice. It’s rather like demonstrating the safety of a food additive by showing that someone doesn’t immediately fall over dead after eating it. (In one absolutely bizarre anecdote, an Argentine sergeant with a “hearing defect” could understand the scrambled analog voice. Datotek fixed its security, but only offered the upgrade to the Argentines, because no one else complained. As I said, no one knew anything.)

In his postscript, he writes that even if the NSA could break Datotek’s products, they were “vastly superior to what [his customers] had used previously.” Given that the previous devices were electromechanical rotor machines, and that his primary competition was a CIA-run operation, he’s probably right. But even today, we know nothing about any other country’s cryptanalytic capabilities during those decades.

A lot of this book has a “you had to be there” vibe. And it’s mostly tone-deaf. There is no real acknowledgment of the human-rights-abusing countries on Datotek’s customer list, and how their products might have assisted those governments. But it’s a fascinating artifact of an era before commercial cryptography went mainstream, before academic cryptography became approved for US classified data, before those of us outside the triple fences of the NSA understood the mathematics of cryptography.

This book review originally appeared in AFIO.

Poet's Corner: two about November

Nov. 13th, 2025 06:40 am
stonepicnicking_okapi: leaves (leaves)
[personal profile] stonepicnicking_okapi
Do you know any poems about November? Here are two well known to me.

---

November Night by Adelaide Crapsey

Listen…
With faint dry sound,
Like steps of passing ghosts,
The leaves, frost-crisp’d, break from the trees
And fall.

---

November for Beginners

Snow would be the easy
way out—that softening
sky like a sigh of relief
at finally being allowed
to yield. No dice.
We stack twigs for burning
in glistening patches
but the rain won’t give.

So we wait, breeding
mood, making music
of decline. We sit down
in the smell of the past
and rise in a light
that is already leaving.
We ache in secret,
memorizing

a gloomy line
or two of German.
When spring comes
we promise to act
the fool. Pour,
rain! Sail, wind,
with your cargo of zithers!

---

'Sail, wind, with your cargo of zithers' should be entered into the vernacular.

Sergeant Taura is, in fact, perfect

Nov. 12th, 2025 11:03 pm
[syndicated profile] lilisonna_tumblr_feed

madgastronomer:

carys-the-ninth:

Vorkosigan Saga has an 8 foot tall genetically engineered super soldier werewolf babe and the only good art I can find of her is this compendium cover:

Why isn’t everybody drawing Sergeant Taura.

Taura is so awesome.

So. If you’re not familiar with the Vorkosigan books, aka the Vorkosigan Saga, they’re the (science fictional) adventures of Miles Vorkosigan (or his parents, Aral and Cordelia, or his brother Mark, or his cousin Ivan-you-idiot). Aral is the Great Man of his generation, a man who won a civil war/uprising against a child emperor, then was regent for the child emperor for more than a decade, then, when Emperor Gregor turned 18, actually handed the Empire to him. Cordelia is the power who stands next to him and keeps him true to himself, while pointing out the foibles of the Empire and its Vor ruling class. Miles is the son with the several disabilities, on a planet where disability, especially birth defects, are deeply taboo.

Some of the books are romances (including pastiches of Georgette Heyer, as well as enemies-to-lovers and a polyamorous romance (sorta)), some are military and/or spy SF (Miles spends several novels as a space mercenary, but he also works for an intelligence agency), some are capers, and more.

It’s 16 novels and 6 shorter works, and it is all excellent (though not all of it is to individual tastes). It follows the family from Aral and Cordelia’s romance to Miles’ decidedly nonstandard birth through his youth and onto his long and varied career, and swings back to Cordelia after Aral’s death. The series, as related above, has a lot to say about birth defects and disabilities, but also a lot to say about things like women in middle age, mourning, death, possible repercussions of future technology, and more.

Taura is someone special. She was genetically engineered to be a slave-supersoldier, was the last survivor of that project, and was imprisoned in a dank basement with only rats to eat.

SPOILERS: Miles found her, was supposed to murder her, decided to bring her out with him instead, and she rescued him as much as he rescued her. Then he hired her and made her a sergeant.

Go read the books if you haven’t already. And draw Sergeant Taura.

Sergeant Taura is, in fact, perfect

Profile

jeshyr: Blessed are the broken. Harry Potter. (Default)
Ricky Buchanan