textproc/moor - 2.9.2
Nov. 27th, 2025 05:21 amChangelog:
https://github.com/walles/moor/releases/tag/v2.9.2
PR: 291189
Reported by: Yusuf Yaman <nxjoseph@protonmail.com> (maintainer)
print/xreader - 4.2.6
Nov. 27th, 2025 05:15 amThis started as a fork of graphics/atril, which in turn forked from
graphics/evince, so move categories to match.
- make PDF and pixbuf support unconditional, support for those
formats are always expected
- optionalise NLS, previewer, thumbnailer
- exclude DOCS as upstream is still evaluating the build issue
textproc/feluda - 1.10.3
Nov. 27th, 2025 04:51 amAdded run-time dependency for emojis to appear properly.
Removed accidentally added distinfo entry of openssl-src (from
previous commit) which we don't want use already.
Changelog:
- https://github.com/anistark/feluda/releases/tag/v1.10.2
- https://github.com/anistark/feluda/releases/tag/v1.10.3
PR: 290737
Reported by: Yusuf Yaman <nxjoseph@protonmail.com> (maintainer)
security/vuxml - 1.1_6
Nov. 27th, 2025 04:19 amdevel/grex - 1.4.6
Nov. 27th, 2025 04:09 amChangelog: https://github.com/pemistahl/grex/releases/tag/v1.4.6
PR: 291219
Reported by: Petteri Valkonen <petteri.valkonen@iki.fi> (maintainer)
Daily Happiness
Nov. 26th, 2025 07:43 pm2. I decided to stop at Handel's for ice cream on my walk and they have a peppermint bark flavor for the holidays! I love peppermint ice cream so this was a must have. It was very tasty. Carla likes peppermint, too, so we'll have to get it again once she's back in town.
3. We are planning to go to Universal Studios around Christmas (well, we decided to go on Christmas actually) because that's when we're blocked out from Disneyland. Neither of us have ever been before, but we want to go to Universal Japan next year on our trip, so I'd really like to be able to compare. Plus we're not renewing our Knott's Berry Farm annual pass for next year and instead considering getting a Universal Studios one, but want to check it out first to see if we would really use it that much (the price is much cheaper than Disneyland, but not as dirt cheap as Knott's). Anyway, while I was poking around on the website to read up for our Christmas trip, I started getting more and more excited about it and decided to do a solo trip myself tomorrow! They have two day passes that get you a deal over buying the dates separately, and you can use the second ticket within 90 days of the first, so I got one to use tomorrow and then will use the other half when we go on Christmas.
4. I finished up one of the big things I was working on at work! It feels so good to have that finally done! And a lot of progress has been made on the other, to the point where we can say we have enough data to move forward by our deadline at the end of next month. There are some things on the IT side that still need to be hammered out, but I think we might not have to delay the project? Fingers crossed!
5. I didn't use a filter for this photo but the lighting made it look like a filter. Gemma loves to hide away on Carla's desk chair when it's pushed under her desk, which of course it is all the time right now since she's not home.

net-im/gotosocial - 0.20.2
Nov. 27th, 2025 02:53 amRelease Notes: https://codeberg.org/superseriousbusiness/gotosocial/releases/tag/v0.20.2
PR: 291222
Reported by: Tilde Joy <tilde@ultros.pro> (maintainer)
Pringle's Science Fiction: The 100 Best Novels, An English-Language Selection, 1949–1984
Nov. 26th, 2025 09:11 pmThe List
( Read more... )
No Beaver Moon
Nov. 26th, 2025 05:37 pm
Was on the lookout the night it was supposed to appear, but there was a lot of cloud cover in the east, and I saw no moon at all that Thursday night.
However we did have a great sunset.
( Read more... )
Alzheimer's Clinical Trial Results, Sadly Running True to Form
Nov. 25th, 2025 01:52 pmThere have been some interesting failures recently in Alzheimer’s trials. As long-time readers will know, I consider basically all Alzheimer’s drug trials to have failed to one degree or another, and particularly when it comes to clearing the “will improve patient’s lives in the real world without putting them at too much risk” hurdle. But these two are notable because they’re aimed outside the usual amyloid zone.
First off, Novo Nordisk reported that semaglutide (the company’s GLP-1 agonist drug, of course) failed in two Alzheimer’s trials. This was going to be a long shot, but long shots are worth taking in this area if you can afford to try them. Studies of thousands of patients with early cognitive impairment who took an oral form of semaglutide (Rybelsus, currently approved as a diabetes therapy) did not show improvements in mental function as compared to placebo. The company says that the treatment group showed “improvement of Alzheimer’s disease-related biomarkers” in both trials, although it does not (as far as I can see) say what those biomarkers were. And I would wonder how good they are as indicators given that you can show improvements in them and still not beat placebo, personally.
The company’s stock took a hit on the news, which is kind of strange. Surely people weren’t betting on this succeeding? But Novo investors have been a jumpy bunch for a while now as Eli Lilly’s star continues to ascend in this area, so the sight of another possible life preserver disappearing might have been enough by itself. At any rate, it does appear as if there’s a disease where GLP-1 drugs are not actually beneficial. Novo had some better news today, though, with a once-weekly shot/once-daily pill combination for amycretin, a dual GLP-1/amylin agonist. I see that people are not quite giving up on the GLP-1/Alzheimer’s idea, but it has to be considered an even longer shot than before.
There’s also new in the anti-tau protein area. That’s long been considered a possible Alzheimer’s target, and by “long” I mean decades. But it’s been hard to put that idea to the test in the clinic. Unfortunately, in the last couple of years it has been possible, and the results have not been good so far. Early last year a Lilly candidate (LY3372689, ceperognastat) failed its own trial. Earlier this year Asceneuron halted work on its own oral anti-tau drug candidate (ASN51), and Biogen stopped BIIB113, another similar effort.
Now all of these are (were) O-GlcNAcase inhibitors, so you could easily make the case that the problem is that might not be a good mechanism to target tau, even if tau itself is a valid idea. But last year Roche bailed on a collaboration for an anti-tau antibody, which went on to fail its trials shortly afterwards. And the latest news is that J&J’s shot at an anti-tau antibody (posdinemab) has also failed its pivotal trial, with no efficacy seen in slowing the disease at the two-year mark. There are other tau programs that are now in the clinic, but they’re clearly going to have to bring something unusual to make you think that they will show interesting levels of efficacy at this point. Good luck, folks. . .
A garden-path headline from the Washington Post
Nov. 26th, 2025 11:01 pmFrom François Lang:
I had to read the first paragraph of this article before being able to parse the headline!
What a perfect storm of ambiguity!
Selected readings
- "Garden paths galore" (1/22/24) — with long list of references
- United States Immigration and Customs Enforcement (ICE; pronounced "ice")
Where in the world is Catherine?
Nov. 26th, 2025 03:17 pmSome things have begun to dawn on me, albeit quite slowly. I'm unbelievably burnt out. Objectively, I knew this, but I'm starting to reckon with the fact that 5 years of nonstop stress and 60-70 hours week have...dented me pretty badly. The last year of deranged boss and constant threat of being fired did not help either. Add to that my age, my cat who needs medical attention and feedings which require me to be at home (even if I wanted to go back to the cube farms) and the IT job market tanking and I'm starting to let go of it. I'm going to focus on ramping up the press, reviving my dormant editing business and seeing what kind of other WFH I can scare up here and there. Eventually, Social Security will have to be a thing, but even with Jana's added in, it won't be enough to live on and I'll have to work anyway.
On the jollier side, I'm writing again! I cranked out 1000 words of novel draft last night, the most I've written at one time in a while. I have 2 other projects in progress and am gradually getting some ideas for other things. I'm going to be pitching some talks and classes and articles as well and working on new story collections as well. I just reactivated my Professional Editors Network membership and will be rebuilding my profile in the next few days. I have a new small business mentor with the county and am meeting with her next week. I found a support group for unemployed older women and will meet with them next week.
And Queen of Swords Press has a terrific new gay vampire novel by M.Christian out and we'll be releasing an omnibus edition of the Astreiant Series by next month on 12/15! The Complete Astreiant by Melissa Scott and Lisa A. Barnett is up for preorder now (please buy direct from us if you can; Amazon is going to crush us on their percentage for this book). The Astreiant Series is also eligible for the Best Series Hugo this year, so please keep it in mind when you are nominating. Melissa Scott has never won a Hugo and I'd love to change that.
Queen of Swords Press is also WisCon's Vendor of the Month for November so if you buy a backlist title (not the preorder) from us using coupon code WisCon26 at checkout, you get a sale price and we'll donate $ to the con. The proverbial win/win!
I'm adding Jana's boxes and journals to the shop on Ko-fi, along with some of my own projects and offerings. Please feel free to boost if the shopping aspects won't work for you.
More bulletins soon! Have a great holiday if you're celebrating! I'm going to veg out with my kitties and do some writing and editing, before enjoying a good takeout meal from the co-op. I'm booked every waking moment Friday, Saturday and part of Sunday so please don't worry that I'm being left to weep alone into my cranberries. I'm deliberately choosing to have a day off. :-)
x11/swaync - 0.12.3
Nov. 26th, 2025 09:56 pmWhile here, pet portlint
www/gatus - 5.33.0
Nov. 26th, 2025 09:46 pmChangeLog: https://github.com/TwiN/gatus/releases/tag/v5.33.0
devel/rust-cbindgen - 0.29.2_5
Nov. 26th, 2025 09:04 pmChangelog:
https://github.com/mozilla/cbindgen/blob/v0.29.2/CHANGES

